Posted June 24, 2025
New Jaundice Guidelines
We are currently working to update our Newborn Jaundice protocols to ensure that they follow the new CPS guidelines. However, this process will take some time and we want to give you some instruction on how to manage in the meantime.
We will now be asked to collect serum albumin in certain instances. Albumin is a water-soluble protein that plays a significant role in neonatal jaundice by binding with bilirubin in the blood, thereby reducing free bilirubin levels that can cross the blood-brain barrier and potentially injure the brain. Higher albumin levels have been shown to have a neuroprotective effect on the newborn brain.
Please follow these steps when you encounter the following situations:
- If a MRP gives you a verbal order to collect an albumin along with the TSB, please fill the microtainer with the green top to the level of the writing or just above that (see photo). This will give enough of a sample to test for both albumin and TSB.
- If a TcB of ≥ 250 µmol/L is detected during our standard TcB screening protocol, please draw a TSB, albumin, and DAT (if it hasn’t been drawn already).
Thank you all for your patience and please do not hesitate to reach out with any feedback or questions that you may have as we navigate these changes to our Newborn Jaundice program.
Posted July 9, 2025
Please ensure that you are up to date with the Tcb protocols.
- Assess for discharge from the “jaundice screening program” if term infant (38 + weeks) and ≥ 48 hours of age; or preterm (35-37/6 weeks) and ≥ 96 hours.
- If term infant and in TcB green zone, may discharge even if <48hrs if clinically well and no risk factors.
- If term infant and in TcB yellow or red zone and <48hrs, follow-up is needed.
- ALL preterm infants (35-37/6 weeks) require follow-up TcB until ≥96hrs regardless of TcB zone.
- If term infant and in TcB yellow zone >48hrs – Routine care – discharge from jaundice screening program.
We have had several incidents recently where a family has requested that the nurse re test for jaundice after the baby has been discharged from the jaundice screening program. This has led to additional visits and blood work that were unnecessary. It is our job to educate the families and ensure that they understand that the baby’s yellow color is not the only factor in determining jaundice. The new CPS guidelines clearly state that ‘Hyperbilirubinemia is a common condition and is usually benign in term and late preterm newborns’. It is a result of an immature liver. Our focus should be on encouraging ‘protective measures like skin to skin contact, breastfeeding support and ensuring feeding effectiveness by monitoring the infant’s weight and urine and stool outputs’.
Our protocols are firmly rooted in the physiology of jaundice. While your clinical judgement at the time of assessment will be supported, please consider the whole picture. If you are considering stepping outside of the protocol, please consult with the Supervisor, Team Leader or family physician first.
Posted October 1, 2025
Discharge guidelines:
Preterm (<38 weeks), ≥96 hrs & ΔTSB 61-89, may discharge from jaundice monitoring program.
Post phototherapy, hyperbili.com will not calculate the ∆TSB nor will it give a recommendation for follow up. You will need to manually calculate the ΔTSB for those babies. Remember we CAN now monitor with TcB if > 18 hours post phototherapy. Once you enter the TcB value and the birth date into hyperbili.com, it will calculate the phototherapy threshold for you.
ΔTSB = Phototherapy threshold – Measured TcB
We will also move to implementing the new language on the white cards. Because JPCH has not implemented the new guidelines, when a chart is triaged, we will still note the jaundice level by color in the bottom right of the white card. When sending your update to the Team Lead, please report the delta value (∆) she will then replace the color on the white card with the delta value. There is a large font laminated card on the white board for easy reference as we learn and implement the new language.
Posted October 8, 2025
Newborn Hyperbilirubinemia Update:
The section on the left is for TcB screenings and resulting ΔTSB.
The section on the right is for TSB screenings and resulting ΔTSB.
You only have one ΔTSB to report at each home visit.
2. There was a great point brought up this week regarding albumin and neurotoxicity risk factors.- Baby born at 38+2 weeks
- No initial neurotoxicity risk factors
- TcB at 83 hrs old was ≥250 µmol/L
- TSB, albumin & DAT were drawn
- Albumin was 28 g/L & DAT was negative
If a baby’s serum albumin is < 30 g/L it is considered hypoalbuminemia and this is a neurotoxicity risk factor. For all future TcB screenings, the baby will have a neurotoxicity risk factor, and this must be entered in the hyperbili.com tool.
Neurotoxicity risk factors? Y/N. This should serve as a helpful way of alerting us to neurotoxicity risk factors when they become present.
Remember:
· Lower albumin levels = neurotoxic






